The value of symptoms and signs in the emergent diagnosis of acute coronary syndromes

2.50
Hdl Handle:
http://hdl.handle.net/2173/108821
Title:
The value of symptoms and signs in the emergent diagnosis of acute coronary syndromes
Authors:
Body, Richard; Carley, Simon; Wibberley, Christopher; McDowell, Garry; Ferguson, Jamie; Mackway-Jones, Kevin
Citation:
Resuscitation, 2010, vol. 81, no. 3, pp. 281-286
Publisher:
Elsevier
Issue Date:
2010
URI:
http://hdl.handle.net/2173/108821
DOI:
10.1016/j.resuscitation.2009.11.014
PubMed ID:
20036454
Additional Links:
http://www.elsevier.com/locate/resuscitation
Abstract:
Patient history and physical examination are widely accepted as cornerstones of diagnosis in modern medicine. We aimed to assess the value of individual historical and examination findings for diagnosing acute myocardial infarction (AMI) and predicting adverse cardiac events in undifferentiated Emergency Department (ED) patients with chest pain. We prospectively recruited patients presenting to the ED with suspected cardiac chest pain. Clinical features were recorded using a custom-designed report form. All patients were followed up for the diagnosis of AMI and the occurrence of adverse events (death, AMI or urgent revascularization) within 6 months.AMI was diagnosed in 148 (18.6%) of the 796 patients recruited. Following adjustment for age, sex and ECG changes, the following characteristics made AMI more likely (adjusted odds ratio, 95% confidence intervals): pain radiating to the right arm (2.23, 1.24–4.00), both arms (2.69, 1.36–5.36), vomiting (3.50, 1.81–6.77), central chest pain (3.29, 1.94–5.61) and sweating observed (5.18, 3.02–8.86). Pain in the left anterior chest made AMI significantly less likely (0.25, 0.14–0.46). The presence of rest pain (0.67, 0.41–1.10) or pain radiating to the left arm (1.36, 0.89–2.09) did not significantly alter the probability of AMI.Our results challenge many widely held assertions about the value of individual symptoms and signs in ED patients with suspected acute coronary syndromes. Several ‘atypical’ symptoms actually render AMI more likely, whereas many ‘typical’ symptoms that are often considered to identify high-risk populations have no diagnostic value.
Type:
Article
Language:
en
Description:
Full-text of this article is not available in this e-prints service. This article was originally published following peer-review in Resuscitation, published by and copyright Elsevier.
Keywords:
Acute myocardial infarction; Clinical features; Physical examination; Diagnosis; Evidence based medicine
ISSN:
0300-9572
EISSN:
1873-1570

Full metadata record

DC FieldValue Language
dc.contributor.authorBody, Richarden
dc.contributor.authorCarley, Simonen
dc.contributor.authorWibberley, Christopheren
dc.contributor.authorMcDowell, Garryen
dc.contributor.authorFerguson, Jamieen
dc.contributor.authorMackway-Jones, Kevinen
dc.date.accessioned2010-08-02T12:59:01Z-
dc.date.available2010-08-02T12:59:01Z-
dc.date.issued2010-
dc.identifier.citationResuscitation, 2010, vol. 81, no. 3, pp. 281-286en
dc.identifier.issn0300-9572-
dc.identifier.pmid20036454-
dc.identifier.doi10.1016/j.resuscitation.2009.11.014-
dc.identifier.urihttp://hdl.handle.net/2173/108821-
dc.descriptionFull-text of this article is not available in this e-prints service. This article was originally published following peer-review in Resuscitation, published by and copyright Elsevier.en
dc.description.abstractPatient history and physical examination are widely accepted as cornerstones of diagnosis in modern medicine. We aimed to assess the value of individual historical and examination findings for diagnosing acute myocardial infarction (AMI) and predicting adverse cardiac events in undifferentiated Emergency Department (ED) patients with chest pain. We prospectively recruited patients presenting to the ED with suspected cardiac chest pain. Clinical features were recorded using a custom-designed report form. All patients were followed up for the diagnosis of AMI and the occurrence of adverse events (death, AMI or urgent revascularization) within 6 months.AMI was diagnosed in 148 (18.6%) of the 796 patients recruited. Following adjustment for age, sex and ECG changes, the following characteristics made AMI more likely (adjusted odds ratio, 95% confidence intervals): pain radiating to the right arm (2.23, 1.24–4.00), both arms (2.69, 1.36–5.36), vomiting (3.50, 1.81–6.77), central chest pain (3.29, 1.94–5.61) and sweating observed (5.18, 3.02–8.86). Pain in the left anterior chest made AMI significantly less likely (0.25, 0.14–0.46). The presence of rest pain (0.67, 0.41–1.10) or pain radiating to the left arm (1.36, 0.89–2.09) did not significantly alter the probability of AMI.Our results challenge many widely held assertions about the value of individual symptoms and signs in ED patients with suspected acute coronary syndromes. Several ‘atypical’ symptoms actually render AMI more likely, whereas many ‘typical’ symptoms that are often considered to identify high-risk populations have no diagnostic value.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.elsevier.com/locate/resuscitationen
dc.subjectAcute myocardial infarctionen
dc.subjectClinical featuresen
dc.subjectPhysical examinationen
dc.subjectDiagnosisen
dc.subjectEvidence based medicineen
dc.titleThe value of symptoms and signs in the emergent diagnosis of acute coronary syndromesen
dc.typeArticleen
dc.identifier.eissn1873-1570-

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