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Title: The role of small vessel disease in development of Alzheimer's disease
Authors: Grau-Slevin, Marta
Arboix, Adria
Gaffney, John
Slevin, Mark
Citation: Neural Regeneration Research, 2010, vol. 5, no. 4, pp. 310-320
Publisher: Neural Regeneration Research
Issue Date: 2010
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Abstract: Classically Alzheimer's disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease (lacunar infarcts, white matter hyperintensities and microbleeds), may magnify the effects of mild Alzheimer's disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. "Vascular hypothesis" of Alzheimer's disease would open a window for new approaches and treatments.
Type: Article
Language: en
Description: Full-text of this article is not available in this e-prints service. This article was originally published following peer-review in Neural Regeneration Research, published by and copyright Neural Regeneration Research.
Keywords: Alzheimer's disease
Small vessel disease
Risk factors
Neuroimaging studies
Histopathological studies
Neurodegenerative disease
Neural regeneration
ISSN: 1673-5374
Appears in Collections: School of Biology, Chemistry and Health Science

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