The role of small vessel disease in development of Alzheimer's disease

2.50
Hdl Handle:
http://hdl.handle.net/2173/108826
Title:
The role of small vessel disease in development of Alzheimer's disease
Authors:
Grau-Slevin, Marta; Arboix, Adria; Gaffney, John; Slevin, Mark
Citation:
Neural Regeneration Research, 2010, vol. 5, no. 4, pp. 310-320
Publisher:
Neural Regeneration Research
Issue Date:
2010
URI:
http://hdl.handle.net/2173/108826
Additional Links:
http://dx.nrronline.org/sites/English/List_2025_9464.html
Abstract:
Classically Alzheimer's disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease (lacunar infarcts, white matter hyperintensities and microbleeds), may magnify the effects of mild Alzheimer's disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. "Vascular hypothesis" of Alzheimer's disease would open a window for new approaches and treatments.
Type:
Article
Language:
en
Description:
Full-text of this article is not available in this e-prints service. This article was originally published following peer-review in Neural Regeneration Research, published by and copyright Neural Regeneration Research.
Keywords:
Alzheimer's disease; Small vessel disease; Development; Risk factors; Diagnosis; Neuroimaging studies; Histopathological studies; Neurodegenerative disease; Neural regeneration
ISSN:
1673-5374

Full metadata record

DC FieldValue Language
dc.contributor.authorGrau-Slevin, Martaen
dc.contributor.authorArboix, Adriaen
dc.contributor.authorGaffney, Johnen
dc.contributor.authorSlevin, Marken
dc.date.accessioned2010-08-02T13:21:12Z-
dc.date.available2010-08-02T13:21:12Z-
dc.date.issued2010-
dc.identifier.citationNeural Regeneration Research, 2010, vol. 5, no. 4, pp. 310-320en
dc.identifier.issn1673-5374-
dc.identifier.urihttp://hdl.handle.net/2173/108826-
dc.descriptionFull-text of this article is not available in this e-prints service. This article was originally published following peer-review in Neural Regeneration Research, published by and copyright Neural Regeneration Research.en
dc.description.abstractClassically Alzheimer's disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease (lacunar infarcts, white matter hyperintensities and microbleeds), may magnify the effects of mild Alzheimer's disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. "Vascular hypothesis" of Alzheimer's disease would open a window for new approaches and treatments.en
dc.language.isoenen
dc.publisherNeural Regeneration Researchen
dc.relation.urlhttp://dx.nrronline.org/sites/English/List_2025_9464.htmlen
dc.subjectAlzheimer's diseaseen
dc.subjectSmall vessel diseaseen
dc.subjectDevelopmenten
dc.subjectRisk factorsen
dc.subjectDiagnosisen
dc.subjectNeuroimaging studiesen
dc.subjectHistopathological studiesen
dc.subjectNeurodegenerative diseaseen
dc.subjectNeural regenerationen
dc.titleThe role of small vessel disease in development of Alzheimer's diseaseen
dc.typeArticleen
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