Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats.

2.50
Hdl Handle:
http://hdl.handle.net/2173/108831
Title:
Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats.
Authors:
Alkreathy, Huda; Damanhouri, Zoheir A.; Ahmed, Nessar; Slevin, Mark; Ali, Soad S.; Osman, Abdel-Moneim M.
Citation:
Food and chemical toxicology , 2010, vol. 48, no. 3, pp. 951-6
Publisher:
Pergamon
Issue Date:
Mar-2010
URI:
http://hdl.handle.net/2173/108831
DOI:
10.1016/j.fct.2010.01.005
PubMed ID:
20060872
Additional Links:
http://www.elsevier.com/wps/find/journaldescription.cws_home/237/description#description
Abstract:
Clinical uses of doxorubicin (DOX), a highly active anticancer agent, are limited by its severe cardiotoxic side effects associated with increased oxidative stress and apoptosis. In this study we investigated whether aged garlic has protective effects against doxorubicin-induced free radical production and cardiotoxicity in male rats. A single dose of doxorubicin (25mg/kg) caused increased both serum cardiac enzymes LDH and CPK activities and a significant increase malonyldialdehyde (MDA) in plasma. However, pretreatment of rats with aged garlic extract (250 mg/kg) for 27 days before doxorubicin therapy, reduced the activity of both enzymes, and significantly decreased of MDA production in plasma. Total antioxidant activity was increased after aged garlic extract administration. Histopathological examination of heart tissue showed that DOX treatment resulted in alteration of cardiac tissue structure in the form of peri arterial fibrosis and apoptotic changes in cardiomyocytes. Pretreatment with aged garlic extract for 27 days ameliorated the effect of DOX administration on cardiac tissue; cardiomyocytes looked more or less similar to those of control. However, still vascular dilatation, mild congestion and interstitial edemas were observed. Our results suggest that aged garlic extract is potentially protective against doxorubicin-induced cardiotoxicity.
Type:
Article
Language:
en
Description:
Full-text of this article is not available in this e-prints service. This article was originally published following peer-review in Food and Chemical Toxicology, published by and copyright Pergamon.
Keywords:
Doxorubicin; Aged garlic extract; Cardiotoxicity
MeSH:
Animals; Antibiotics, Antineoplastic; Antioxidants; Doxorubicin; Garlic; Glycosylation End Products, Advanced; Heart Diseases; Indicators and Reagents; Lipid Peroxides; Male; Malondialdehyde; Myocardium; Myocytes, Cardiac; Plant Extracts; Rats; Rats, Wistar
ISSN:
0278-6915
EISSN:
1873-6351

Full metadata record

DC FieldValue Language
dc.contributor.authorAlkreathy, Hudaen
dc.contributor.authorDamanhouri, Zoheir A.en
dc.contributor.authorAhmed, Nessaren
dc.contributor.authorSlevin, Marken
dc.contributor.authorAli, Soad S.en
dc.contributor.authorOsman, Abdel-Moneim M.en
dc.date.accessioned2010-08-02T13:53:38Z-
dc.date.available2010-08-02T13:53:38Z-
dc.date.issued2010-03-
dc.identifier.citationFood and chemical toxicology , 2010, vol. 48, no. 3, pp. 951-6en
dc.identifier.issn0278-6915-
dc.identifier.pmid20060872-
dc.identifier.doi10.1016/j.fct.2010.01.005-
dc.identifier.urihttp://hdl.handle.net/2173/108831-
dc.descriptionFull-text of this article is not available in this e-prints service. This article was originally published following peer-review in Food and Chemical Toxicology, published by and copyright Pergamon.en
dc.description.abstractClinical uses of doxorubicin (DOX), a highly active anticancer agent, are limited by its severe cardiotoxic side effects associated with increased oxidative stress and apoptosis. In this study we investigated whether aged garlic has protective effects against doxorubicin-induced free radical production and cardiotoxicity in male rats. A single dose of doxorubicin (25mg/kg) caused increased both serum cardiac enzymes LDH and CPK activities and a significant increase malonyldialdehyde (MDA) in plasma. However, pretreatment of rats with aged garlic extract (250 mg/kg) for 27 days before doxorubicin therapy, reduced the activity of both enzymes, and significantly decreased of MDA production in plasma. Total antioxidant activity was increased after aged garlic extract administration. Histopathological examination of heart tissue showed that DOX treatment resulted in alteration of cardiac tissue structure in the form of peri arterial fibrosis and apoptotic changes in cardiomyocytes. Pretreatment with aged garlic extract for 27 days ameliorated the effect of DOX administration on cardiac tissue; cardiomyocytes looked more or less similar to those of control. However, still vascular dilatation, mild congestion and interstitial edemas were observed. Our results suggest that aged garlic extract is potentially protective against doxorubicin-induced cardiotoxicity.en
dc.language.isoenen
dc.publisherPergamonen
dc.relation.urlhttp://www.elsevier.com/wps/find/journaldescription.cws_home/237/description#descriptionen
dc.subjectDoxorubicinen
dc.subjectAged garlic extracten
dc.subjectCardiotoxicityen
dc.subject.meshAnimals-
dc.subject.meshAntibiotics, Antineoplastic-
dc.subject.meshAntioxidants-
dc.subject.meshDoxorubicin-
dc.subject.meshGarlic-
dc.subject.meshGlycosylation End Products, Advanced-
dc.subject.meshHeart Diseases-
dc.subject.meshIndicators and Reagents-
dc.subject.meshLipid Peroxides-
dc.subject.meshMale-
dc.subject.meshMalondialdehyde-
dc.subject.meshMyocardium-
dc.subject.meshMyocytes, Cardiac-
dc.subject.meshPlant Extracts-
dc.subject.meshRats-
dc.subject.meshRats, Wistar-
dc.titleAged garlic extract protects against doxorubicin-induced cardiotoxicity in rats.en
dc.typeArticleen
dc.identifier.eissn1873-6351-

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