2.50
Hdl Handle:
http://hdl.handle.net/2173/109482
Title:
Effects of smoking on tibial and radial bone mass and strength may diminish with age.
Authors:
Wüst, Robert C.I.; Winwood, Keith L.; Wilks, Désirée C.; Morse, Christopher I.; Degens, Hans; Rittweger, Jörn
Citation:
The Journal of clinical endocrinology and metabolism, 2010, vol. 95, no. 6, pp. 2763-71
Publisher:
The Endocrine Society
Issue Date:
Jun-2010
URI:
http://hdl.handle.net/2173/109482
DOI:
10.1210/jc.2009-2462
PubMed ID:
20375208
Additional Links:
http://jcem.endojournals.org/
Abstract:
PURPOSE: The purpose of the study was to assess the effect of cigarette smoking on indicators of bone strength across a wide age range, controlling for physical activity and neuromuscular performance. METHODS: We conducted a cross-sectional study with 41 smokers (mean age +/- SD, 41.0 +/- 16.1 yr) and 53 nonsmokers (47.5 +/- 18.2 yr) of both sexes. Bone strength indicators (BSI) were assessed in the lower leg and forearm by peripheral quantitative computed tomography along with physical activity, muscle cross-sectional area, and maximal voluntary muscle force. RESULTS: Physical activity level and muscle cross-sectional area of the leg and arm were similar in smokers and nonsmokers. Although trabecular volumetric bone mineral density and epiphyseal bone mineral content, both indicators of BSI, decreased with age in the nonsmokers' tibia (P < 0.001), this was not observed in the smokers (interaction age x smoking: P = 0.014 and P = 0.032 for density and content, respectively). Regression coefficients were nonsignificant in nonsmokers, whereas coefficients in smokers were -1.24 mg/cm x yr [95% confidence interval (CI) = -2.16-0.33; P = 0.01] for content and -1.20 mg/cm(3) x yr (95% CI = -1.76-0.62; P < 0.001) for trabecular density. The BSI values in the smokers were independent of their smoking history (r(2) = 0.000-0.021), and no effects of sex were observed in the smoking-related differences in BSI. CONCLUSIONS: Smoking compromises bone strength by diaphyseal marrow cavity expansion and epiphyseal trabecular bone content reductions. These effects seem to wane with age. The causes of the attenuated effect of smoking on bone at old age remain enigmatic but might be linked to an interaction between the smoke-related factors and senescence processes affecting bone.
Type:
Article
Language:
en
Description:
Full-text of this article is not available in this e-prints service. This article was originally published following peer-review in Journal of Clinical Endocrinology and Metabolism, published by and copyright The Endocrine Society.
MeSH:
Adult; Aging; Case-Control Studies; Cross-Sectional Studies; Female; Forearm; Humans; Image Processing, Computer-Assisted; Leg; Male; Middle Aged; Motor Activity; Muscle Strength; Radius; Sex Characteristics; Smoking; Tibia; Tomography, X-Ray Computed
ISSN:
1945-7197; 0021-972X

Full metadata record

DC FieldValue Language
dc.contributor.authorWüst, Robert C.I.en
dc.contributor.authorWinwood, Keith L.en
dc.contributor.authorWilks, Désirée C.en
dc.contributor.authorMorse, Christopher I.en
dc.contributor.authorDegens, Hansen
dc.contributor.authorRittweger, Jörnen
dc.date.accessioned2010-08-11T13:47:51Z-
dc.date.available2010-08-11T13:47:51Z-
dc.date.issued2010-06-
dc.identifier.citationThe Journal of clinical endocrinology and metabolism, 2010, vol. 95, no. 6, pp. 2763-71en
dc.identifier.issn1945-7197-
dc.identifier.issn0021-972X-
dc.identifier.pmid20375208-
dc.identifier.doi10.1210/jc.2009-2462-
dc.identifier.urihttp://hdl.handle.net/2173/109482-
dc.descriptionFull-text of this article is not available in this e-prints service. This article was originally published following peer-review in Journal of Clinical Endocrinology and Metabolism, published by and copyright The Endocrine Society.en
dc.description.abstractPURPOSE: The purpose of the study was to assess the effect of cigarette smoking on indicators of bone strength across a wide age range, controlling for physical activity and neuromuscular performance. METHODS: We conducted a cross-sectional study with 41 smokers (mean age +/- SD, 41.0 +/- 16.1 yr) and 53 nonsmokers (47.5 +/- 18.2 yr) of both sexes. Bone strength indicators (BSI) were assessed in the lower leg and forearm by peripheral quantitative computed tomography along with physical activity, muscle cross-sectional area, and maximal voluntary muscle force. RESULTS: Physical activity level and muscle cross-sectional area of the leg and arm were similar in smokers and nonsmokers. Although trabecular volumetric bone mineral density and epiphyseal bone mineral content, both indicators of BSI, decreased with age in the nonsmokers' tibia (P < 0.001), this was not observed in the smokers (interaction age x smoking: P = 0.014 and P = 0.032 for density and content, respectively). Regression coefficients were nonsignificant in nonsmokers, whereas coefficients in smokers were -1.24 mg/cm x yr [95% confidence interval (CI) = -2.16-0.33; P = 0.01] for content and -1.20 mg/cm(3) x yr (95% CI = -1.76-0.62; P < 0.001) for trabecular density. The BSI values in the smokers were independent of their smoking history (r(2) = 0.000-0.021), and no effects of sex were observed in the smoking-related differences in BSI. CONCLUSIONS: Smoking compromises bone strength by diaphyseal marrow cavity expansion and epiphyseal trabecular bone content reductions. These effects seem to wane with age. The causes of the attenuated effect of smoking on bone at old age remain enigmatic but might be linked to an interaction between the smoke-related factors and senescence processes affecting bone.en
dc.language.isoenen
dc.publisherThe Endocrine Societyen
dc.relation.urlhttp://jcem.endojournals.org/en
dc.subject.meshAdult-
dc.subject.meshAging-
dc.subject.meshCase-Control Studies-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshFemale-
dc.subject.meshForearm-
dc.subject.meshHumans-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshLeg-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMotor Activity-
dc.subject.meshMuscle Strength-
dc.subject.meshRadius-
dc.subject.meshSex Characteristics-
dc.subject.meshSmoking-
dc.subject.meshTibia-
dc.subject.meshTomography, X-Ray Computed-
dc.titleEffects of smoking on tibial and radial bone mass and strength may diminish with age.en
dc.typeArticleen

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