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Title: Mortality predictors in disabling chronic obstructive pulmonary disease in old age
Authors: Yohannes, Abebaw M.
Baldwin, Robert C.
Connolly, Martin J.
Citation: Age and ageing, 2002, vol.31, no. 2, pp. 137-4
Publisher: Oxford University Press
Issue Date: Mar-2002
PubMed ID: 11937477
Additional Links:
Abstract: OBJECTIVE: prospectively to evaluate predictors of mortality in elderly patients with disabling chronic obstructive pulmonary disease. METHODS: 137 (69 men) outpatients, aged 60-89 (mean 73) years with symptomatic disabling chronic obstructive pulmonary disease. We collected baseline demographic and physiological data. Subjects completed the Manchester Respiratory Activities of Daily Living Questionnaire, the Brief Assessment Schedule Depression Cards a screening questionnaire for depression, the Breathing Problems Questionnaire measuring quality of life, and the Montgomery Asberg Depression Rating Scale measuring severity of depression. All subjects were followed prospectively and survival and mortality data were confirmed by contacting general practitioners and scrutinising hospital notes at 30 months. RESULTS: the mean (standard deviation) of one second forced expiratory volume was 0.89 (0.3) litres. At 30 months, 44 patients (21 men, aged 61-89 [mean 75] years: 32% of the total) had died. Mean (standard deviation) baseline one second forced expiratory volume of those dying was 0.71 (0.2) litres. On logistic regression analysis, predictors of mortality were: Manchester Respiratory Activities Of Daily Living Questionnaire score (odds ratio=0.88, 95% confidence interval=0.80-0.97); pre-bronchodilator one second forced expiratory volume (odds ratio=0.04, confidence interval=0.005-0.32); body mass index (odds ratio=0.87, confidence interval=0.79-0.97); and long term oxygen therapy (odds ratio=3.17, confidence interval=1.04-8.36). Current smoking status, pack-years smoked, depression scores, quality of life scores, co-morbid diseases and social class did not predict mortality. CONCLUSION: disability, use of long-term oxygen therapy, pre-bronchodilator lung function and body-mass index were independent predictors of mortality in elderly patients with severe chronic obstructive pulmonary disease.
Type: Article
Language: en
Description: This metadata relates to an article accepted for publication in [journal title] following peer review. The definitive publisher-authenticated version, Yohannes, A.M et al. Mortality predictors in disabling chronic obstructive pulmonary disease in old age, Age and ageing, 2002, vol. 31, no. 2, pp. 137-140 is available online at:
MeSH: Activities of Daily Living
Aged, 80 and over
Chronic Disease
Disabled Persons
Great Britain
Logistic Models
Middle Aged
Predictive Value of Tests
Prospective Studies
Pulmonary Disease, Chronic Obstructive
Quality of Life
Severity of Illness Index
Survival Analysis
Time Factors
ISSN: 0002-0729
EISSN: 1468-2834
Appears in Collections: Department of Health Professions
Department of Nursing

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