Endurance training modulates the muscular transcriptome response to acute exercise

2.50
Hdl Handle:
http://hdl.handle.net/2173/90125
Title:
Endurance training modulates the muscular transcriptome response to acute exercise
Authors:
Flüeck, Martin; Schmutz, Silvia; Däpp, Christoph; Wittwer, Matthias; Vogt, Michael; Hoppeler, Hans
Citation:
Pflügers archiv - European journal of physiology, 2006, vol. 451, no. 5, pp. 678-687
Publisher:
Springer
Issue Date:
Feb-2006
URI:
http://hdl.handle.net/2173/90125
DOI:
10.1007/s00424-005-1497-0
Additional Links:
http://link.springer.de/link/service/journals/00424/index.htm
Abstract:
We hypothesized that in untrained individuals (n=6) a single bout of ergometer endurance exercise provokes a concerted response of muscle transcripts towards a slow-oxidative muscle phenotype over a 24-h period. We further hypothesized this response during recovery to be attenuated after six weeks of endurance training. We monitored the expression profile of 220 selected transcripts in muscle biopsies before as well as 1, 8, and 24 h after a 30-min near-maximal bout of exercise. The generalized gene response of untrained vastus lateralis muscle peaked after 8 h of recovery (P=0.001). It involved multiple transcripts of oxidative metabolism and glycolysis. Angiogenic and cell regulatory transcripts were transiently reduced after 1 h independent of the training state. In the trained state, the induction of most transcripts 8 h after exercise was less pronounced despite a moderately higher relative exercise intensity, partially because of increased steady-state mRNA concentration, and the level of metabolic and extracellular RNAs was reduced during recovery from exercise. Our data suggest that the general response of the transcriptome for regulatory and metabolic processes is different in the trained state. Thus, the response is specifically modified with repeated bouts of endurance exercise during which muscle adjustments are established.
Type:
Article
Language:
en
Description:
The original publication is available at http://www.springer.com/
Keywords:
Endurance exercise; Gene expression; Skeletal muscle; Structure; Time course
ISSN:
0031-6768; 1432-2013

Full metadata record

DC FieldValue Language
dc.contributor.authorFlüeck, Martinen
dc.contributor.authorSchmutz, Silviaen
dc.contributor.authorDäpp, Christophen
dc.contributor.authorWittwer, Matthiasen
dc.contributor.authorVogt, Michaelen
dc.contributor.authorHoppeler, Hansen
dc.date.accessioned2010-01-20T14:09:00Z-
dc.date.available2010-01-20T14:09:00Z-
dc.date.issued2006-02-
dc.identifier.citationPflügers archiv - European journal of physiology, 2006, vol. 451, no. 5, pp. 678-687en
dc.identifier.issn0031-6768-
dc.identifier.issn1432-2013-
dc.identifier.doi10.1007/s00424-005-1497-0-
dc.identifier.urihttp://hdl.handle.net/2173/90125-
dc.descriptionThe original publication is available at http://www.springer.com/en
dc.description.abstractWe hypothesized that in untrained individuals (n=6) a single bout of ergometer endurance exercise provokes a concerted response of muscle transcripts towards a slow-oxidative muscle phenotype over a 24-h period. We further hypothesized this response during recovery to be attenuated after six weeks of endurance training. We monitored the expression profile of 220 selected transcripts in muscle biopsies before as well as 1, 8, and 24 h after a 30-min near-maximal bout of exercise. The generalized gene response of untrained vastus lateralis muscle peaked after 8 h of recovery (P=0.001). It involved multiple transcripts of oxidative metabolism and glycolysis. Angiogenic and cell regulatory transcripts were transiently reduced after 1 h independent of the training state. In the trained state, the induction of most transcripts 8 h after exercise was less pronounced despite a moderately higher relative exercise intensity, partially because of increased steady-state mRNA concentration, and the level of metabolic and extracellular RNAs was reduced during recovery from exercise. Our data suggest that the general response of the transcriptome for regulatory and metabolic processes is different in the trained state. Thus, the response is specifically modified with repeated bouts of endurance exercise during which muscle adjustments are established.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://link.springer.de/link/service/journals/00424/index.htmen
dc.subjectEndurance exerciseen
dc.subjectGene expressionen
dc.subjectSkeletal muscleen
dc.subjectStructureen
dc.subjectTime courseen
dc.titleEndurance training modulates the muscular transcriptome response to acute exerciseen
dc.typeArticleen
All Items in e-space are protected by copyright, with all rights reserved, unless otherwise indicated.