Investigation of food and environmental exposures relating to the epidemiology of Campylobacter coli in humans in Northwest England

2.50
Hdl Handle:
http://hdl.handle.net/2173/94420
Title:
Investigation of food and environmental exposures relating to the epidemiology of Campylobacter coli in humans in Northwest England
Authors:
Sopwith, Will; Birtles, Andrew; Matthews, Margaret; Fox, Andrew J.; Gee, Steven; James, Sam; Kempster, Jeanette; Painter, Michael; Edwards-Jones, Valerie; Osborn, Keith; Regan, Martyn; Syed, Qutub; Bolton, Eric
Citation:
Applied and environmental microbiology, 2010, vol. 76, no. 1, pp. 129-135
Publisher:
American Society for Microbiology
Publication Date:
Jan-2010
URI:
http://hdl.handle.net/2173/94420
DOI:
10.1128/AEM.00942-09
PubMed ID:
19854914
Additional Links:
http://aem.asm.org/
Abstract:
This study uses multilocus sequence typing (MLST) to investigate the epidemiology of Campylobacter coli in a continuous study of a population in Northwest England. All cases of Campylobacter identified in four Local Authorities (government administrative boundaries) between 2003 and 2006 were identified to species level and then typed, using MLST. Epidemiological information was collected for each of these cases, including food and recreational exposure variables, and the epidemiologies of C. jejuni and C. coli were compared using case-case methodology. Samples of surface water thought to represent possible points of exposure to the populations under study were also sampled, and campylobacters were typed with multilocus sequence typing. Patients with C. coli were more likely to be older and female than patients with C. jejuni. In logistic regression, C. coli infection was positively associated with patients eating undercooked eggs, eating out, and reporting problems with their water supply prior to illness. C. coli was less associated with consuming pork products. Most of the cases of C. coli yielded sequence types described elsewhere in both livestock and poultry, but several new sequence types were also identified in human cases and water samples. There was no overlap between types identified in humans and surface waters, and genetic analysis suggested three distinct clades but with several "intermediate" types from water that were convergent with the human clade. There is little evidence to suggest that epidemiological differences between human cases of C. coli and C. jejuni are a result of different food or behavioral exposures alone.
Type:
Article
Language:
en
Description:
Full-text of this article is not available in this e-prints service. This article was originally published following peer-review in Applied and Environmental Microbiology, published by and copyright American Society for Microbiology.
ISSN:
0099-2240; 1098-5336

Full metadata record

DC FieldValue Language
dc.contributor.authorSopwith, Willen
dc.contributor.authorBirtles, Andrewen
dc.contributor.authorMatthews, Margareten
dc.contributor.authorFox, Andrew J.en
dc.contributor.authorGee, Stevenen
dc.contributor.authorJames, Samen
dc.contributor.authorKempster, Jeanetteen
dc.contributor.authorPainter, Michaelen
dc.contributor.authorEdwards-Jones, Valerieen
dc.contributor.authorOsborn, Keithen
dc.contributor.authorRegan, Martynen
dc.contributor.authorSyed, Qutuben
dc.contributor.authorBolton, Ericen
dc.date.accessioned2010-03-17T11:49:24Z-
dc.date.available2010-03-17T11:49:24Z-
dc.date.issued2010-01-
dc.identifier.citationApplied and environmental microbiology, 2010, vol. 76, no. 1, pp. 129-135en
dc.identifier.issn0099-2240-
dc.identifier.issn1098-5336-
dc.identifier.pmid19854914-
dc.identifier.doi10.1128/AEM.00942-09-
dc.identifier.urihttp://hdl.handle.net/2173/94420-
dc.descriptionFull-text of this article is not available in this e-prints service. This article was originally published following peer-review in Applied and Environmental Microbiology, published by and copyright American Society for Microbiology.en
dc.description.abstractThis study uses multilocus sequence typing (MLST) to investigate the epidemiology of Campylobacter coli in a continuous study of a population in Northwest England. All cases of Campylobacter identified in four Local Authorities (government administrative boundaries) between 2003 and 2006 were identified to species level and then typed, using MLST. Epidemiological information was collected for each of these cases, including food and recreational exposure variables, and the epidemiologies of C. jejuni and C. coli were compared using case-case methodology. Samples of surface water thought to represent possible points of exposure to the populations under study were also sampled, and campylobacters were typed with multilocus sequence typing. Patients with C. coli were more likely to be older and female than patients with C. jejuni. In logistic regression, C. coli infection was positively associated with patients eating undercooked eggs, eating out, and reporting problems with their water supply prior to illness. C. coli was less associated with consuming pork products. Most of the cases of C. coli yielded sequence types described elsewhere in both livestock and poultry, but several new sequence types were also identified in human cases and water samples. There was no overlap between types identified in humans and surface waters, and genetic analysis suggested three distinct clades but with several "intermediate" types from water that were convergent with the human clade. There is little evidence to suggest that epidemiological differences between human cases of C. coli and C. jejuni are a result of different food or behavioral exposures alone.en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.urlhttp://aem.asm.org/en
dc.titleInvestigation of food and environmental exposures relating to the epidemiology of Campylobacter coli in humans in Northwest Englanden
dc.typeArticleen

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